Analytical Data
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基因名
PAX2
- Application
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别名
PAX2；Paired box Protein Pax-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02962
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表达区间
1-388aa
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氨基酸序列
MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPEAAVGPSSSLMSKPGRKLAEVPPCVQPTGASSPATRTATPSTRPTTRL
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分子量
68.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAX2 is a member of the paired box family of transcription factors, playing a crucial role in the development of various tissues, particularly in the kidneys, eyes, and central nervous system. Abnormal expression or mutation of PAX2 has been linked to congenital disorders such as renal agenesis and ocular anomalies. Due to its significant roles in embryogenesis and organogenesis, PAX2 has gained attention as a potential therapeutic target for regenerative medicine and cancer. Researchers have focused on the recombinant expression of PAX2 to understand its functional properties, interaction with other proteins, and regulatory mechanisms. The production of PAX2 recombinant protein allows for detailed biochemical studies, including binding affinity assays and reporter gene analyses, which help elucidate its role in gene expression regulation. Furthermore, examining PAX2's structure through techniques like X-ray crystallography and NMR spectroscopy can provide insights into its DNA-binding domains and potential for specificity towards target genes. This research not only enhances our understanding of PAX2’s developmental functions but also paves the way for its application in clinical settings, particularly in correcting dysregulation associated with various diseases. Overall, the study of PAX2 recombinant protein is pivotal for unveiling the complexities of its biological pathways and exploring innovative therapeutic avenues.
