Analytical Data
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基因名
FLG
- Application
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别名
FLG;Filaggrin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20930
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表达区间
3838-4061aa
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氨基酸序列
DSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHSGIQSRGSPHSSSSYHYQSEGTERQKGQSGLVWRHGSYGSADYDYGESGFRHSQHGSVSYNSNPVVFKERSDICKASAFGKDHPRYYATYINKDPGLCGHSSDISKQLGFSQSQRYYYYE
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分子量
39.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of FLG (filaggrin) recombinant proteins has gained significant attention due to their critical role in skin barrier function and the pathogenesis of various dermatological conditions. Filaggrin is a key protein in the epidermis, involved in the aggregation of keratin filaments, which contributes to the structural integrity of the skin. Deficiencies or mutations in the FLG gene have been linked to atopic dermatitis, ichthyosis vulgaris, and other skin disorders, highlighting the protein's importance in maintaining skin hydration and barrier properties. Researchers are increasingly focusing on recombinant FLG proteins as a potential therapeutic approach to restore skin barrier function and alleviate symptoms in affected individuals. By employing techniques such as recombinant DNA technology and protein engineering, scientists aim to produce functional FLG proteins that can be used in skin care products or as treatments for skin conditions. This research not only aims to enhance our understanding of skin biology but also to develop innovative therapeutic strategies to improve the quality of life for individuals suffering from skin-related diseases. Overall, the exploration of FLG recombinant proteins holds promise for advancing dermatological therapies and expanding our knowledge of the interplay between genetics and skin health.












