Analytical Data
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Gene name
CCR7/CD197
- Application
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Alternative Names
CD197; CCR7; BLR2; CDw197; CMKBR7; EBI1; Epstein-Barr Virus Induced Protein 1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32248
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Expression Region
Asn290~Pro378
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Protein Length
Partial
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Molecular Weight
16kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR7, also known as CD197, is a chemokine receptor that plays a crucial role in the immune system by directing the migration of lymphocytes and antigen-presenting cells to secondary lymphoid organs. It is particularly important for the homing of T cells and dendritic cells, facilitating their interactions that are essential for initiating and regulating adaptive immune responses. Understanding CCR7/CD197 is pivotal for various applications, including the development of immunotherapies for cancer and the enhancement of vaccine efficacy. The generation of recombinant CCR7/CD197 proteins enables researchers to study the receptor's structure, function, and interactions in detail. This research contributes to elucidating the mechanisms underlying immune cell trafficking and can lead to novel therapeutic strategies. Furthermore, elucidating the signaling pathways activated by CCR7/CD197 may provide insights into immune-related diseases where dysregulation of this receptor occurs, such as in chronic inflammation or autoimmune disorders. The study of CCR7/CD197 also has significant implications in the context of HIV and other viral infections, where the manipulation of immune cell migration can affect the pathogenesis and treatment outcomes. Overall, the investigation of CCR7/CD197 recombinant proteins is essential for advancing our understanding of immune responses and for the potential development of targeted therapies.
