Analytical Data
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Gene name
CCR5
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简介
CCR5 protein is a receptor for inflammatory CC chemokines, including CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, and plays a crucial role in signal transduction by increasing intracellular calcium levels. . It acts as a chemoattractant receptor and contributes to granulocyte lineage control and T lymphocyte migration to sites of infection. CCR5 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived CCR5 protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
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Alternative Names
C-C chemokine receptor type 5; CHEMR13; HIV-1 fusion coreceptor
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Species
Mouse
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Source
P. pastoris
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51682
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Expression Region
Q263-L354
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCR5, a chemokine receptor, plays a crucial role in immune responses and serves as a primary co-receptor for HIV-1 entry into host cells, making it a significant target for therapeutic interventions. The understanding of CCR5's role in HIV infection initiated extensive research into its structure and function, leading to the development of CCR5 antagonists as potential antiviral agents. Additionally, the CCR5-delta 32 mutation, which provides resistance to HIV infection, has spurred interest in CCR5 as a target for gene editing and immunotherapy strategies. Researchers have focused on generating recombinant CCR5 proteins to study their biochemical properties, signaling pathways, and interactions with ligands and antibodies. Such studies are essential for unraveling the mechanisms of HIV pathogenesis and for designing effective therapies, including vaccines and monoclonal antibodies. The advances in recombinant DNA technology have facilitated the production of CCR5 proteins for use in experimental assays, enabling the exploration of CCR5's structural and functional dynamics. Overall, the ongoing research into CCR5 recombinant proteins represents a promising avenue for developing innovative approaches to combat HIV/AIDS and enhance our understanding of immune regulation.
