Analytical Data
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基因名
CCR5
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简介
CCR5 protein is a receptor for inflammatory CC chemokines, including CCL3/MIP-1-alpha, CCL4/MIP-1-beta, and RANTES, and plays a crucial role in signal transduction by increasing intracellular calcium levels. . It acts as a chemoattractant receptor and contributes to granulocyte lineage control and T lymphocyte migration to sites of infection. CCR5 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived CCR5 protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
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别名
C-C chemokine receptor type 5; CHEMR13; HIV-1 fusion coreceptor
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种属
Mouse
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表达系统
P. pastoris
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51682
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表达区间
Q263-L354
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR5, a chemokine receptor, plays a crucial role in immune responses and serves as a primary co-receptor for HIV-1 entry into host cells, making it a significant target for therapeutic interventions. The understanding of CCR5's role in HIV infection initiated extensive research into its structure and function, leading to the development of CCR5 antagonists as potential antiviral agents. Additionally, the CCR5-delta 32 mutation, which provides resistance to HIV infection, has spurred interest in CCR5 as a target for gene editing and immunotherapy strategies. Researchers have focused on generating recombinant CCR5 proteins to study their biochemical properties, signaling pathways, and interactions with ligands and antibodies. Such studies are essential for unraveling the mechanisms of HIV pathogenesis and for designing effective therapies, including vaccines and monoclonal antibodies. The advances in recombinant DNA technology have facilitated the production of CCR5 proteins for use in experimental assays, enabling the exploration of CCR5's structural and functional dynamics. Overall, the ongoing research into CCR5 recombinant proteins represents a promising avenue for developing innovative approaches to combat HIV/AIDS and enhance our understanding of immune regulation.
