Analytical Data
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Gene name
yopM
- Application
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Alternative Names
yopM; yop48; YPCD1.26c; y5054; y0059; YP_pCD60; Outer membrane protein YopM
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Species
Yersinia pestis
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17778
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Expression Region
1-409aa
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Molecular Weight
62.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
YopM is a virulence factor encoded by the Yersinia pestis and Yersinia pseudotuberculosis species, which are responsible for diseases such as plague and Yersiniosis, respectively. The protein plays a critical role in evading the host immune response, thereby facilitating bacterial survival and proliferation during infection. Research into YopM has gained considerable interest due to its unique structure and function, particularly its ability to interfere with host cell signaling pathways. This interference can hinder the activation of immune responses, allowing the bacterium to persist undetected within the host. Recent studies have highlighted the importance of YopM in modulating the host's inflammatory response, with implications for understanding the mechanisms of pathogenesis associated with Yersinia infections. Furthermore, the recombinant production of YopM has become a focus area, enabling detailed investigation of its biological activities and potential use as a target for therapeutic interventions. By exploring the functional properties of YopM, researchers aim to develop novel strategies to combat Yersinia-related diseases, enhancing our overall understanding of bacterial virulence and host-pathogen interactions. This research is not only significant for its potential clinical applications but also contributes to the broader field of microbiology by providing insights into the evolution of virulence factors across pathogenic species.
