Analytical Data
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基因名
CHM
- Application
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别名
Choroideremia protein Rab escort protein 1 Short name:REP-1 TCD protein
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24386
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表达区间
1-653aa
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分子量
77.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of CHM recombinant proteins is rooted in the growing interest in understanding the molecular mechanisms underlying various genetic disorders and the development of targeted therapies. CHM, or Choroideremia, is a rare X-linked recessive genetic disease caused by mutations in the CHM gene, leading to progressive vision loss due to retinal degeneration. Research into the recombinant protein form of the CHM gene aims to explore its functional properties and potential therapeutic applications, as understanding the structure and function of this protein can provide insights into disease mechanisms. Additionally, the production of CHM recombinant proteins allows for the development of gene therapy approaches and protein replacement strategies that could potentially restore function in affected individuals. Recent advances in genetic engineering techniques enable the efficient expression and purification of these proteins, facilitating both in vitro and in vivo studies. Such research is critical not only for potentially developing effective treatments for Choroideremia but also for broader implications in the fields of ophthalmology and gene therapy, enhancing our overall understanding of retinal diseases and genetic disorders.












