Analytical Data
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Gene name
KRT23
- Application
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Alternative Names
K23; HAIK1; CK23; K23; Keratin, type I cytoskeletal 23; Cytokeratin-23
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C075
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Expression Region
Asp243~Thr382
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Molecular Weight
24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT23, also known as keratin 23, is a member of the keratin family, which plays a crucial role in the structural integrity and function of epithelial tissues. This protein is primarily found in the hair follicles and is associated with various skin conditions, making it a subject of interest in dermatological research. Recent studies suggest that KRT23 may be involved in cellular processes such as proliferation, differentiation, and apoptosis, implicating it in the pathology of diseases like psoriasis and other keratinization disorders. Additionally, the expression patterns of KRT23 can provide insights into specific cellular responses to environmental stimuli and stress. The understanding of KRT23's role at the molecular level could facilitate the development of targeted therapeutics for skin-related diseases. Researchers are increasingly focusing on the recombinant expression of KRT23 to explore its biological functions, interactions with other proteins, and potential as a biomarker for skin disorders. Insights from such studies may pave the way for innovations in the treatment and diagnosis of conditions involving keratin dysregulation.
