Recombinant Mouse VANGL1 Protein，His

VANGL1 (Vang-like 1) is a key protein involved in the regulation of planar cell polarity (PCP) and has garnered significant attention in developmental biology and disease research. PCP is a fundamental biological process that orients cells and tissues in a uniform manner, crucial for the development of various organs and structures, particularly in the nervous system. Aberrant regulation of VANGL1 has been implicated in several congenital disorders, such as neural tube defects and ciliopathies, due to its role in mediating signaling pathways that dictate cellular orientation and alignment. Additionally, VANGL1 has been linked to cancer progression, where its dysregulation may influence tumor cell morphology and metastatic behavior. The recombinant study of VANGL1 allows researchers to explore its structure-function relationship, interaction with other PCP components, and its role in signaling cascades at a molecular level. This research is essential for understanding VANGL1’s diverse functions in health and disease, paving the way for potential therapeutic targets in conditions arising from PCP dysregulation. The recombination techniques utilized to produce VANGL1 facilitate detailed investigations into its biological mechanisms, contributing to a broader understanding of PCP and its implications in developmental biology and oncology.