Analytical Data
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Gene name
ATP13A3
- Application
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Alternative Names
AFURS1; ATPase Family Homolog Up Regulated In Senescence Cells; Probable cation-transporting ATPase 13A3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H7F0
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Expression Region
Met50~Ser202
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Molecular Weight
48kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP13A3 is a member of the P-type ATPase family, which is implicated in various cellular processes, including ion transport and cellular homeostasis. This protein is particularly interesting due to its association with neurological disorders, such as Kufor-Rakeb syndrome and other forms of parkinsonism. ATP13A3 is believed to contribute to the regulation of cellular zinc levels and lysosomal function, which are critical for neuronal health and function. The study of ATP13A3 recombinant proteins has gained momentum in recent years as researchers aim to elucidate its structure, function, and potential pathogenic mechanisms. By expressing and purifying recombinant ATP13A3, scientists can investigate its biochemical properties, interaction with metal ions, and effects on cellular signaling pathways. Understanding the role of ATP13A3 in cellular physiology and its implications in disease could lead to the development of therapeutic strategies targeting its dysfunction, thereby providing insight into neurodegenerative processes. Given the growing interest in lysosomal function and neurodegeneration, research on ATP13A3 recombinant proteins represents a pivotal area of study that holds promise for advancing our knowledge of these critical biological pathways.
