Analytical Data
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基因名
ASF1B
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简介
The ASF1B protein is an important histone chaperone that crucially promotes histone deposition and coordinates exchange and removal during nucleosome assembly and disassembly, which has been verified by various studies. ASF1B cooperates with CAF-1 to promote replication-dependent chromatin assembly. ASF1B Protein, Human (sf9, His) is the recombinant human-derived ASF1B protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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别名
Histone chaperone ASF1B; hAsf1b; CCG1-interacting factor A-II; CIA-II
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种属
Human
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表达系统
Baculovirus
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NVP2
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表达区间
M1-I202
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蛋白长度
Full Length
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ASF1B (Asf1 Histone Chaperone B) is a vital protein involved in chromatin remodeling and histone management during DNA replication and repair. It functions as a histone chaperone, facilitating the assembly and disassembly of histone proteins on DNA, thus playing a crucial role in maintaining genome stability and regulating gene expression. Research into ASF1B has gained significant attention due to its implications in various biological processes and its potential links to cancer. Aberrant expression of ASF1B has been associated with several tumor types, suggesting that it could serve as a biomarker for cancer progression or a therapeutic target. Recent studies have focused on understanding the structural characteristics of ASF1B, its interaction with other chromatin-associated factors, and the mechanisms through which it contributes to DNA damage response and repair. The ability to produce recombinant ASF1B protein has facilitated these investigations, enabling detailed biochemical and biophysical studies that illuminate its functional properties. Understanding the precise role of ASF1B in cellular processes not only enhances our knowledge of epigenetic regulation but also opens up avenues for therapeutic interventions in diseases linked to chromatin dysregulation. The ongoing research into ASF1B is pivotal for uncovering the complexities of chromatin dynamics and its impact on cellular health and disease.
