Analytical Data
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基因名
Profilin-2
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简介
Profilin-2 protein is a key player in protein folding. It specifically binds to cytosolic chaperone protein (c-CPN) and promotes the transfer of target proteins. It also interacts with nascent polypeptide chains, helping unnatural proteins fold correctly in various competing pathways. Profilin-2 Protein, Human is the recombinant human-derived Profilin-2 protein, expressed by E. coli , with tag free.
- Application
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别名
Profilin-II; PFN2; Profilin-2; PFL
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35080-1
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表达区间
M1-F140
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蛋白长度
Full Length of Isoform-1
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分子量
14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Profilin-2 is a key actin-binding protein that plays a vital role in the regulation of the actin cytoskeleton, influencing numerous cellular processes such as cell motility, shape, and division. It is specifically expressed in the brain and testes, suggesting specialized functions in neuronal and germ cell development. Research on Profilin-2 has garnered attention due to its potential involvement in various neurological disorders, including autism spectrum disorders and schizophrenia, where altered actin dynamics may contribute to synaptic dysfunction. The recombinant production of Profilin-2 allows for detailed studies of its biochemical properties, interactions with other proteins, and its regulatory mechanisms on actin polymerization. Understanding Profilin-2 at the molecular level could reveal novel therapeutic targets for conditions associated with cytoskeletal abnormalities. Recent advances in recombinant DNA technology facilitate the expression and purification of this protein, enabling comprehensive in vitro and in vivo studies. With ongoing investigations into its structure and function, Profilin-2 remains a significant focus in the field of neurobiology and cell biology, opening avenues for breakthroughs in understanding complex cellular phenomena and diseases.
