Analytical Data
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Gene name
MICA
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简介
MHC class I chain-related protein A (MICA) is a highly polymorphic major histocompatability complex class I chain-related protein A. MICA is expressed on the cell surface and is a ligand for the NKG2-D type II integral membrane protein receptor and functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, MICA has been associated with susceptibility to psoriasis 1 and psoriatic arthritis. MICA Protein, Human (HEK293, His-Avi) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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Alternative Names
FLJ60820; MGC111087; MICA; PERB11.1; DAMA-345G11.2; FLJ36918; FLJ60820; MGC21250
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96QC4
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Expression Region
E24-Q308
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Protein Length
Partial
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Molecular Weight
55-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MICA (MHC class I polypeptide-related sequence A) is a protein that plays a crucial role in the immune system by acting as a ligand for the NKG2D receptor found on natural killer (NK) cells and some T cells. Research into MICA has gained significant attention due to its involvement in the regulation of immune responses, particularly in tumor immunity and autoimmune diseases. MICA is often upregulated in stressed, infected, or malignant cells, allowing the immune system to recognize and eliminate these abnormal cells. However, its overexpression can also contribute to immune evasion by tumors, leading to poor prognosis in cancer patients. The study of recombinant MICA proteins has facilitated investigations into their structural properties, biological functions, and interactions with other immune components, providing insights into their potential therapeutic applications. Understanding MICA's role in immune modulation has opened avenues for developing novel immunotherapies aimed at enhancing anti-tumor responses or mitigating autoimmune conditions. Additionally, research on MICA polymorphisms and their influence on individual susceptibility to diseases further underscores its importance in immunogenetics. Overall, MICA's multifaceted involvement in immune regulation makes it a significant target for research in immunology and therapeutic development.
