Analytical Data
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基因名
PIGL
- Application
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别名
N-Acetylglucosaminylphosphatidylinositol Deacetylase; Phosphatidylinositol Glycan Anchor Biosynthesis,Class L; N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2B2
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表达区间
Met1~Leu252
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIGL (Phosphatidylinositol glycan anchor biosynthesis class L) is an essential enzyme involved in the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway, which is crucial for the post-translational modification of various glycoproteins on the cell surface. GPI anchors play significant roles in cellular processes, including cell signaling, adhesion, and immune responses. Defects in GPI anchor synthesis can lead to a range of disorders, including neurodegenerative diseases and immunodeficiencies. Recent studies have highlighted the importance of PIGL in the assembly of GPI anchors and its potential role in disease mechanisms. Understanding the structure and function of PIGL is vital for elucidating the biochemical pathways that govern GPI anchor biosynthesis and for developing therapeutic strategies for related disorders. Recombinant PIGL protein is generated to study its enzymatic activity, substrate specificity, and interaction with other proteins in the GPI anchor synthesis pathway. These studies aim to provide insights into the functional implications of PIGL in cellular processes and its involvement in pathophysiological conditions, paving the way for targeted interventions in diseases linked to GPI anchor deficiencies.
