Analytical Data
-
基因名
SH3BP2
- Application
-
别名
CRBM; RES4-23; Cherubism
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P78314
-
表达区间
Met1~Leu259
-
分子量
42kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SH3BP2, or SH3 domain-binding protein 2, is a crucial adaptor protein that plays a significant role in various cellular processes, including signal transduction, cytoskeletal remodeling, and cell migration. It is characterized by multiple protein-protein interaction domains, enabling it to interact with various signaling molecules and scaffolding proteins. Research has increasingly focused on SH3BP2 due to its implications in immune responses and its association with several diseases, particularly those related to bone development and hematological disorders. Mutations in the SH3BP2 gene have been linked to familial expansile osteolysis, highlighting its importance in bone metabolism. Furthermore, SH3BP2 has been shown to modulate the activity of Rho-family GTPases, which are crucial for the regulation of cytoskeletal dynamics. As such, understanding the functional characteristics and interactions of the SH3BP2 protein can provide valuable insights into its role in pathophysiology and uncover potential therapeutic targets for conditions like osteoporosis or immune-related diseases. Ongoing studies involving recombinant SH3BP2 proteins aim to elucidate its structural features and interaction dynamics, contributing to a broader understanding of its biological functions and the mechanisms underlying related disorders.
