Analytical Data
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基因名
SULF1
- Application
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别名
HSULF-1; Extracellular sulfatase Sulf-1
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种属
Human
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表达系统
E. coli
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标签
Two N- s, His- & SUMO-
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IWU6
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表达区间
Pro609~Gly871
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分子量
45&35kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SULF1, a member of the sulfatase family, is an important enzyme that plays a critical role in the regulation of heparan sulfate (HS) proteoglycans, which are pivotal in various biological processes, including cell signaling, development, and tumorigenesis. Research into SULF1 has gained attention due to its potential implications in cancer biology, particularly in modulating the activity of growth factors and their receptors. Elevated levels of SULF1 have been associated with various cancer types, where it may contribute to tumor progression by altering the HS landscape and impacting signaling pathways such as Wnt and FGF. Additionally, SULF1 has been implicated in the regulation of stem cell behavior and the tumor microenvironment, making it a promising target for therapeutic interventions. Recent studies have focused on the structural and functional characterization of the recombinant SULF1 protein, aiming to elucidate its enzymatic mechanisms and interactions with HS substrates. Understanding SULF1's role at the molecular level could inform novel strategies for cancer treatment and regenerative medicine. Overall, the study of SULF1 and its recombinant protein holds significant promise for enhancing our understanding of cell biology and developing targeted therapies for malignancies where heparan sulfate dysregulation plays a key role.
