Analytical Data
-
Gene name
ATP1a4
- Application
-
Alternative Names
ATP1A1; ATP1AL2; TPase Na+/K+ Transporting Alpha Polypeptide-Like 2; Sodium pump subunit alpha-4; Sodium/potassium-transporting ATPase subunit alpha-4
-
Species
Rat
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q64541
-
Expression Region
Met1~Pro92
-
Molecular Weight
17kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATP1a4, a member of the Na+/K+ ATPase family, plays a crucial role in maintaining ionic homeostasis in various tissues, particularly in the nervous system. This protein is an essential enzyme that hydrolyzes ATP to facilitate the active transport of sodium and potassium ions across the plasma membrane, thereby regulating membrane potential and cellular excitability. Research has shown that ATP1a4 is particularly involved in the function of neurons, influencing neurotransmitter release and synaptic transmission. Its expression and activity levels can be affected by physiological and pathological conditions, making it a potential target for studying neurological diseases and disorders. Furthermore, the reconstitution of ATP1a4 as a recombinant protein provides valuable insights into the structure-function relationships of this enzyme and its mechanisms of ion transport. By generating ATP1a4 in a controlled laboratory setting, researchers can investigate its biochemical properties, analyze its interactions with pharmacological agents, and explore its role in cellular signaling pathways. Understanding the detailed functioning of ATP1a4 is essential for elucidating its contribution to neuronal function and for developing therapeutic strategies for conditions associated with dysregulated ion transport.
