Analytical Data
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Gene name
TARC/CCL17
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简介
TARC/CCL17 Protein, Mouse (70a.a) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Mouse is a recombinant mouse TARC/CCL17(A34-P103) protein expressed by E. coli[1][2].
- Application
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Alternative Names
rMuTARC/CCL17; C-C motif chemokine 17; SCYA17
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Species
Mouse
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
F6R5P4
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Expression Region
A34-P103
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Protein Length
Full Length of Mature Protein
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Molecular Weight
9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TARC (Thymus and Activation-Regulated Chemokine) and CCL17 are chemokines belonging to the CC chemokine family, primarily involved in immune responses, notably in the recruitment of T cells and other immune cells to sites of inflammation. Research on TARC/CCL17 has gained prominence due to its significant role in various allergic and autoimmune diseases, such as asthma, atopic dermatitis, and psoriasis. Elevated levels of TARC/CCL17 have been correlated with the severity of these conditions, making it a potential biomarker for disease progression and treatment efficacy. Furthermore, its interaction with specific receptors, such as CCR4, highlights its importance in mediating immune cell migration. The development of recombinant TARC/CCL17 proteins facilitates the exploration of their biological functions, receptor interactions, and potential therapeutic applications. These proteins can be utilized in in vitro studies to understand their roles in immune modulation and inflammation. Additionally, they hold promise for the development of targeted therapies aimed at manipulating the immune response in allergic and autoimmune disorders. Overall, TARC/CCL17 recombinant protein research is essential for understanding immune mechanisms and exploring new avenues for treatment.
