Analytical Data
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Gene name
FOXJ1
- Application
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Alternative Names
FOX-J1; HFH4; FKHL13; Forkhead-related protein FKHL13; Hepatocyte nuclear factor 3 forkhead homolog 4
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q61660
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Expression Region
Ser168~Leu421
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Molecular Weight
40kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FOXJ1, a member of the Forkhead box family of transcription factors, plays a critical role in the regulation of genes associated with ciliary biogenesis and function. Its expression is predominantly observed in tissues that exhibit motile cilia, such as the respiratory epithelium, where it is essential for maintaining proper ciliary structure and function. Dysregulation of FOXJ1 has been linked to various diseases, including primary ciliary dyskinesia, which is characterized by impaired ciliary movement leading to respiratory issues. Research into FOXJ1 recombinant proteins has gained traction as scientists seek to elucidate its precise biological functions and potential therapeutic applications. By producing FOXJ1 in a recombinant form, researchers aim to study its interaction with ciliary proteins and other cellular pathways in vitro and in vivo. This approach not only aids in understanding ciliary assembly mechanisms but also opens doors for novel diagnostic and therapeutic strategies targeting ciliary-related disorders. Furthermore, the investigation of FOXJ1's role in regulating stem cell differentiation and tissue repair processes highlights its importance in developmental biology and regenerative medicine. Understanding the molecular mechanisms underlying FOXJ1 function could pave the way for innovative treatments for conditions stemming from ciliary dysfunction, thereby underscoring the significance of FOXJ1 recombinant protein studies in both basic and applied biomedical research.
