Analytical Data
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Gene name
AARS2
- Application
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Alternative Names
AARSL; AlaRS; Alanyl-tRNA Synthetase Like; Alanyl-tRNA synthetase
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
D3ZX08
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Expression Region
Val721~Leu985
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
AARS2, or Alanyl-tRNA Synthetase 2, is a crucial enzyme involved in protein synthesis, specifically in the charging of tRNA molecules with alanine. Mutations in the AARS2 gene have been linked to various mitochondrial disorders and neurodegenerative diseases, highlighting its importance in cellular metabolism and function. The enzyme plays a critical role in mitochondrial protein translation, impacting the production of essential proteins necessary for mitochondrial integrity and energy production. Recent studies have focused on the structure and function of AARS2, aiming to elucidate its role in disease mechanisms and its potential as a therapeutic target. The investigation of AARS2 recombinant proteins has provided valuable insights into its catalytic mechanisms and interaction with tRNAs, paving the way for understanding how specific mutations can disrupt enzymatic function and lead to disease. Furthermore, the characterization of AARS2 recombinant proteins can assist in developing targeted therapies and improving comprehension of mitochondrial biology. Overall, the research on recombinant AARS2 proteins serves as a foundation for advancing knowledge in mitochondrial diseases and exploring innovative treatment strategies.
