Analytical Data
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基因名
NPR2
- Application
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别名
Atrial natriuretic peptide receptor type B
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种属
Human
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表达系统
Baculovirus
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20594
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表达区间
23-458aa
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分子量
52.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPR2 (Natriuretic Peptide Receptor 2) is a key player in the natriuretic peptide signaling pathway, which regulates various physiological processes, including blood pressure, fluid balance, and vascular homeostasis. Research into NPR2 has gained prominence due to its critical role in cardiovascular health and its potential implications in various pathologies, such as heart failure and hypertension. NPR2 is a membrane-bound receptor that, upon activation by natriuretic peptides, initiates intracellular signaling cascades that influence the activity of guanylate cyclase, leading to increased levels of cyclic guanosine monophosphate (cGMP). This molecule acts as a second messenger mediating vasodilatory effects and promoting natriuresis. Mutations in the NPR2 gene have been linked to several conditions, including familial idiopathic short stature, showcasing its importance in growth regulation. The recombinant NPR2 protein has garnered interest in research and therapeutic applications, as it can be used to study receptor mechanics, signaling pathways, and potential drug interactions. Understanding the structure and function of NPR2 through recombinant protein studies can pave the way for developing targeted therapies that may alleviate conditions related to dysregulated natriuretic signaling. Overall, the research on NPR2 and its recombinant protein is vital for advancing our knowledge of cardiovascular health and addressing related disorders through innovative therapeutic strategies.
