Analytical Data
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Gene name
BAG4
- Application
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Alternative Names
SODD; Silencer Of Death Domains; BAG family molecular chaperone regulator 4
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8CI61
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Expression Region
Ser210~Ala447
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Molecular Weight
35&33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAG4, a member of the BAG (BCL2-associated athanogene) family, plays a crucial role in regulating cellular stress responses, apoptosis, and protein homeostasis. Research on BAG4 has gained momentum due to its potential implications in various diseases, including cancer and neurodegenerative disorders. Unlike its relatives, BAG4 has unique properties that allow it to interact with multiple signaling pathways and molecular chaperones, particularly Hsp70 and Hsp90, which are vital in managing protein folding and degradation. Investigating BAG4's structure and function can reveal insights into its mechanisms in cellular contexts and its involvement in disease progression. The reconstitution of BAG4 as a recombinant protein is essential for elucidating its biochemical properties, facilitating the study of its interactions, and assessing its functional roles. Furthermore, as BAG4 has been implicated in promoting cell survival under stress conditions, understanding its molecular dynamics could pave the way for novel therapeutic strategies targeting BAG4 in various pathological states. Thus, the study of recombinant BAG4 protein is critical for advancing our knowledge of its biological functions and therapeutic potential.
