Analytical Data
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Gene name
AMOTL2
- Application
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Alternative Names
LCCP; Leman Coiled-Coil Protein
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2J4
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Expression Region
Met1~Arg230
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Molecular Weight
55kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
AMOTL2 (Angiomotin Like 2) is a member of the angiomotin family of proteins, which are primarily involved in various cellular processes such as cell migration, proliferation, and the regulation of tight junctions. Research into AMOTL2 has gained momentum due to its significant roles in physiological and pathological contexts, particularly in tumorigenesis and cancer metastasis. This protein is known to interact with several regulatory pathways, including those associated with Hippo signaling, which is crucial for controlling cell growth and maintaining tissue homeostasis. Dysregulation of AMOTL2 has been implicated in various cancer types, where it may influence tumor progression by modulating cellular behaviors and the tumor microenvironment. Moreover, studies have shown that AMOTL2 can affect angiogenesis and vascular permeability, further elevating its interest in the context of cancer research. Additionally, its potential as a therapeutic target has prompted efforts to investigate AMOTL2 as a biomarker for cancer diagnosis and prognosis. Understanding the full scope of AMOTL2's functions and mechanisms through recombinant protein studies could yield valuable insights into its contributions to cellular dynamics and reveal novel approaches for cancer treatment. Thus, the research surrounding AMOTL2 is critical for elucidating the intricate networks that govern cellular behavior and disease progression, representing a promising avenue for therapeutic intervention in oncology.
