Analytical Data
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基因名
ARHGDIb
- Application
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别名
D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P52566
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表达区间
Thr2~Glu201
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分子量
53kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGDIb, or Rho GDP-dissociation inhibitor beta, is a critical regulatory protein that modulates the activity of Rho-type GTPases, which are pivotal in various cellular processes, including cytoskeletal dynamics, cell migration, and signal transduction. The dysregulation of Rho GTPases has been implicated in numerous pathological conditions such as cancer, cardiovascular diseases, and neurological disorders. Research into ARHGDIb has gained momentum due to its potential as a therapeutic target; however, a comprehensive understanding of its structure and function is still emerging. Various recombinant protein expression methods have been employed to produce ARHGDIb for biochemical and biophysical studies. These studies aim to elucidate the protein's interaction mechanisms with Rho GTPases and its regulatory role in the cell. By investigating the structural and functional properties of ARHGDIb, researchers hope to identify novel biomarkers and therapeutic strategies for diseases associated with Rho GTPase pathways. Overall, the continued exploration of ARHGDIb is vital for advancing our understanding of cellular regulation and developing targeted interventions for related diseases.
