Analytical Data
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基因名
BIRC3
- Application
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别名
AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; Apoptosis Inhibitor 2; TNFR2-TRAF Signaling Complex Protein; Mammalian IAP Homolog C; Inhibitor Of Apoptosis Protein 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13489
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表达区间
Lys439~Gln529
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分子量
14kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BIRC3, a member of the inhibitor of apoptosis protein (IAP) family, plays a critical role in regulating cell survival and apoptosis. It serves as a powerful anti-apoptotic factor, inhibiting caspases and modulating various signaling pathways, particularly the NF-κB pathway, which is pivotal in immune responses and inflammation. Dysregulation of BIRC3 has been linked to several malignancies, including lymphomas and leukemias, highlighting its importance in cancer biology. Researchers have sought to understand the structure and function of BIRC3 to unravel its mechanisms of action and explore its potential as a therapeutic target. The development of recombinant BIRC3 proteins has enabled detailed studies of its biochemical properties and interactions with other cellular components. These studies have further illustrated how BIRC3 influences apoptosis and cell proliferation, providing insights into novel strategies for cancer treatments. By generating BIRC3 recombinant proteins, scientists can investigate its role in various cellular contexts and evaluate its potential as a biomarker or therapeutic target in oncological and immunological diseases. The ongoing research aims to clarify the complex role of BIRC3 in cell fate decisions, advancing our understanding of apoptosis regulation and its implications for cancer therapy.
