Analytical Data
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Gene name
CFP-10
- Application
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Alternative Names
10KDA culture filtrate antigen CFP-10 Secreted antigenic protein MTSA-10
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Species
Mycobacterium tuberculosis
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P9WNK4
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Expression Region
2-100aa
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Molecular Weight
14.7
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CFP-10, or cultured filtrate protein 10, is a prominent secreted protein produced by Mycobacterium tuberculosis, the pathogen responsible for tuberculosis (TB). This protein has garnered significant interest in the field of infectious disease research due to its role in modulating host immune responses. Studies have shown that CFP-10 is involved in evading the host's immune system, aiding the bacterium in establishing and maintaining infection. It acts as a virulence factor by interacting with immune cells, leading to altered cytokine production and influencing macrophage function. The investigation of CFP-10 has important implications for understanding TB pathogenesis and could potentially contribute to the development of novel diagnostic tools and therapeutic strategies. Furthermore, CFP-10, along with its partner protein ESAT-6, is pivotal in the formulation of innovative vaccines aimed at enhancing immunity against TB. Given the global health burden posed by tuberculosis and the rise of drug-resistant strains, elucidating the functional mechanisms of CFP-10 could offer crucial insights into improving TB control measures and developing effective interventions. Researchers are exploring the detailed structural and functional characteristics of CFP-10, identifying its role in host-pathogen interactions, and assessing its potential as a biomarker for TB infection. Overall, the study of CFP-10 represents a vital area in the quest for improved understanding and management of tuberculosis, particularly in the context of emerging public health challenges.
