Analytical Data
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Gene name
HCRTR2
- Application
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Alternative Names
Hypocretin receptor type 2
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Species
Human
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Source
Yeast
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43614
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Expression Region
1-75aa
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Molecular Weight
10.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HCRTR2, or the hypocretin receptor 2, is a G-protein coupled receptor crucial for regulating various physiological functions, including arousal, appetite, and sleep-wake cycles. Its interest in research has surged in recent years due to its significant role in sleep disorders, particularly narcolepsy, where hypocretin-producing neurons are diminished. Understanding the structure and function of HCRTR2 can provide insights into the mechanisms underlying these disorders and reveal potential therapeutic targets. The study of recombinant HCRTR2 proteins is vital for elucidating receptor dynamics, ligand binding, and downstream signaling pathways. By utilizing techniques such as protein expression, purification, and characterization, researchers aim to explore the receptor’s pharmacology and its interactions with endogenous ligands, specifically orexin A and B. Ultimately, this research not only advances our comprehension of sleep regulation but also opens avenues for developing novel pharmacological agents to treat sleep-related conditions and other metabolic disorders linked to the hypcretin system.
