Analytical Data
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基因名
HCRTR2
- Application
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别名
Hypocretin receptor type 2
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种属
Human
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43614
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表达区间
1-75aa
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分子量
10.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HCRTR2, or the hypocretin receptor 2, is a G-protein coupled receptor crucial for regulating various physiological functions, including arousal, appetite, and sleep-wake cycles. Its interest in research has surged in recent years due to its significant role in sleep disorders, particularly narcolepsy, where hypocretin-producing neurons are diminished. Understanding the structure and function of HCRTR2 can provide insights into the mechanisms underlying these disorders and reveal potential therapeutic targets. The study of recombinant HCRTR2 proteins is vital for elucidating receptor dynamics, ligand binding, and downstream signaling pathways. By utilizing techniques such as protein expression, purification, and characterization, researchers aim to explore the receptor’s pharmacology and its interactions with endogenous ligands, specifically orexin A and B. Ultimately, this research not only advances our comprehension of sleep regulation but also opens avenues for developing novel pharmacological agents to treat sleep-related conditions and other metabolic disorders linked to the hypcretin system.
