Analytical Data
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Gene name
KAL
- Application
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Alternative Names
SERPINA4; KLST; KST; PI4; Serpin Peptidase Inhibitor Clade A Member 4; Tissue Kallikrein Inhibitor; Kallikrein Binding Protein; Peptidase inhibitor 4
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29622
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Expression Region
Gln21~Pro427
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Molecular Weight
50kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KAL, or Kallmann syndrome protein, plays a pivotal role in the development of the olfactory system and the regulation of gonadotropin-releasing hormone (GnRH) secretion. Kallmann syndrome, a genetic disorder characterized by the absence of puberty and an impaired sense of smell, is directly linked to mutations in the KAL gene. This gene encodes a protein responsible for the migration of GnRH neurons from the olfactory bulb to the hypothalamus during embryonic development. Recent research has focused on the biochemical properties and interactions of KAL, revealing its involvement in neurogenic and reproductive processes. The study of KAL and its protein structure aims to elucidate the molecular mechanisms underlying Kallmann syndrome, potentially leading to novel therapeutic approaches for restoring GnRH function and addressing associated reproductive disorders. Furthermore, understanding KAL's role in neuronal signaling pathways may provide insights into broader implications in neurodevelopmental disorders. As researchers utilize advanced techniques such as recombinant DNA technology and protein purification, the exploration of KAL’s functional characteristics and its interactions with other proteins is expected to contribute significantly to the fields of developmental biology and endocrinology.
