Analytical Data
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基因名
ATXN10
- Application
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别名
E46L; SCA10; Spinocerebellar Ataxia 10; Brain protein E46 homolog
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBB4
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表达区间
Leu116~Ala302
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分子量
25KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATXN10, or Ataxin-10, is a protein encoded by the ATXN10 gene, which is implicated in certain neurodegenerative disorders, most notably spinocerebellar ataxia type 10 (SCA10). SCA10 is characterized by progressive ataxia and cognitive decline, and it is linked to an expanded hexanucleotide repeat in the ATXN10 gene. Recent studies have focused on the molecular mechanisms underlying ATXN10's function and the effects of its mutations. Research has revealed that ATXN10 may be involved in RNA metabolism and cellular stress responses, and its dysregulation can lead to neurodegeneration. Additionally, ATXN10 has been shown to interact with other proteins linked to various cellular pathways, further complicating its role in disease. The production and characterization of recombinant ATXN10 protein allows researchers to investigate these interactions and functions in vitro, facilitating the understanding of SCA10 pathogenesis and potentially guiding therapeutic strategies. Understanding how ATXN10 behaves in a controlled environment is crucial for uncovering its precise mechanisms and developing targeted interventions for SCA10 and related disorders.
