Analytical Data
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Gene name
TNPO2
- Application
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Alternative Names
IPO3; KPNB2B; TRN2; Importin 3; Karyopherin Beta 2b
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14787
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Expression Region
Leu17~Leu248
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TNPO2 (Transportin 2) is a member of the karyopherin family, which plays a crucial role in nucleocytoplasmic transport, particularly in the import of proteins containing nuclear localization signals. Recent studies have indicated that TNPO2 is involved in several important cellular processes, including cell proliferation, differentiation, and response to stress. Its role in viral infections, particularly in the importation of viral proteins into the nucleus, has garnered significant attention in virology research. Moreover, TNPO2 has been implicated in various diseases, including cancer, where its overexpression has been associated with tumor progression and poor prognosis. This has sparked interest in the development of TNPO2-targeted therapeutic strategies. The recombinant expression of TNPO2 protein in various systems, such as bacteria or mammalian cells, facilitates the study of its structure-function relationship and interaction with other cellular proteins. Understanding TNPO2's mechanism of action can provide insights into its potential as a biomarker or therapeutic target. Given the increasing recognition of its biological significance, ongoing research aims to elucidate the precise roles of TNPO2 in cellular homeostasis and disease development, thereby paving the way for innovative interventions in TNPO2-related pathologies.
