Analytical Data
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Gene name
CCL6
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简介
The CCL6 protein is part of the intercrine beta family, a component of chemokines involved in intercellular communication and immune responses. In this family, CCL6 may play an important role in regulating inflammatory processes and cellular interactions. CCL6 Protein, Rat (N-His) is the recombinant rat-derived CCL6 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Biological Activity
Measured in a cell proliferation assay using HUVEC cells.The ED50 for this effect is 15.84 ng/mL, corresponding to a specific activity is 6.313×104 units/mg. Measured in a cell proliferation assay using HUVEC cells.The ED50 for this effect is 15.84 ng/mL, corresponding to a specific activity is 6.313×104 units/mg.
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Alternative Names
Ccl6C-C motif chemokine 6; Small-inducible cytokine A6
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Species
Rat
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
Q68FP3
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Expression Region
G22-A115
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Protein Length
Full Length of Mature Protein
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL6, also known as liver-derived chemokine (LDC), is a member of the C-C motif chemokine family and plays a crucial role in the immune response and inflammation. Its primary function involves attracting immune cells to sites of injury or infection, thereby influencing various physiological and pathophysiological processes. In recent years, research has increasingly focused on CCL6 due to its potential implications in various diseases, including autoimmune disorders, cancer, and chronic inflammation. Studies have demonstrated that CCL6 is involved in modulating the migration and activation of T cells and monocytes, highlighting its importance in both innate and adaptive immunity. Recombinant CCL6 protein is utilized in laboratory settings to investigate its signaling pathways and interactions with specific receptors, offering insights into its functions and mechanisms. Furthermore, understanding the role of CCL6 in disease progression may lead to the development of novel therapeutic strategies, such as targeted therapies that aim to modulate its activity. The exploration of CCL6 not only enhances our comprehension of immune regulation but also opens avenues for innovative approaches to treat diseases characterized by dysregulated immune responses. Overall, research on recombinant CCL6 protein holds significant promise for elucidating the complexities of immune system dynamics and the development of potential clinical applications.
