Analytical Data
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Gene name
Intelectin-1/ITLN1
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简介
Intelectin-1/ITLN1 is a lectin with specific affinity for microbial carbohydrate chains and recognizes β-linked D-galactofuranosose, D-glycerolphosphate modified glycans, D-glycerol-D-talo-oct- 2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-keto acid (KDO). It binds to bacterial glycans and helps defend against microorganisms. Intelectin-1/ITLN1 Protein, Human (N-His, C-myc) is the recombinant human-derived Intelectin-1/ITLN1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.
- Application
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Alternative Names
ITLN1; intelectin 1 (galactofuranose binding); intelectin-1; FLJ20022; hIntL; HL 1; ITLN; LFR; ITLN-1; endothelial lectin HL-1; galactofuranose-binding lectin; intestinal lactoferrin receptor; HL1; HL-1; INTL; omentin
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Species
Human
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Source
E. coli
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Tag
N-10*His;C-Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WWA0
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Expression Region
T19-S298
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Protein Length
Full Length of Mature Protein
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Intelectin-1 (ITLN1) is a member of the intelectin family of proteins, which are involved in innate immunity and are known for their role in recognizing carbohydrates present on pathogens and modulating immune responses. Research has shown that ITLN1 is predominantly expressed in intestinal tissues and plays a crucial role in maintaining gut health by binding to certain glycan structures on the surface of bacteria, thereby facilitating their clearance and influencing gut microbiota composition. Elevated levels of ITLN1 have been associated with various inflammatory conditions, including ulcerative colitis, Crohn's disease, and even obesity, underscoring its potential as a biomarker for gastrointestinal diseases. The recombinant form of ITLN1 has gained attention for its therapeutic applications, allowing for detailed studies into its functional properties, interactions with pathogens, and its utility in diagnostics. By exploring the mechanisms through which ITLN1 operates, researchers aim to uncover novel approaches for enhancing gut immunity and developing targeted therapies for related disorders. Thus, the study of recombinant ITLN1 not only contributes to the understanding of immune system dynamics but also highlights its potential significance in clinical applications, making it a compelling focus for ongoing research in immunology and gastrointestinal health.
