Analytical Data
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基因名
TIAM1
- Application
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13009
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表达区间
Asp1261~Lys1397
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分子量
19kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIAM1, or T-cell lymphoma invasion and metastasis 1, is a member of the guanine nucleotide exchange factor family that plays a crucial role in regulating cell migration, adhesion, and signaling pathways, particularly in the context of cancer progression and metastasis. Research has shown that TIAM1 is involved in various cellular processes, including the activation of Rho GTPases, which are critical for actin cytoskeleton remodeling and cell motility. Elevated TIAM1 expression has been associated with aggressive tumor phenotypes in several cancers, highlighting its potential as a biomarker for cancer prognosis. Additionally, TIAM1 influences the interaction between cancer cells and the tumor microenvironment, affecting their invasive capabilities. Given its significant role in tumor biology, there is a growing interest in developing TIAM1 as a therapeutic target. Recombinant TIAM1 protein studies aim to elucidate its molecular mechanisms, interactions with other proteins, and contributions to the signaling pathways that govern cancer cell behavior. Understanding the structure and function of TIAM1 can pave the way for novel therapeutic strategies to inhibit its activity in malignant cells, potentially leading to improved treatment options for cancer patients. Through the characterization of recombinant TIAM1, researchers can investigate its role in cell signaling and migration, providing insights into the mechanisms underlying tumor metastasis and the development of targeted therapies.
