Analytical Data
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Gene name
GLIPR1
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简介
GLIPR1 protein is a member of the CRISP (cysteine-rich secreted protein) family and is a multifunctional protein involved in a variety of cellular processes. It is primarily known for its role in cancer development and progression. GLIPR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GLIPR1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Glioma Pathogenesis-Related Protein 1; GliPR 1; Protein RTVP-1; GLIPR1; GLIPR; RTVP1
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9CWG1
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Expression Region
S18-T223
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AA Sequence
SSFTASTLPDITNEDFIKECVQVHNQLRSKVSPPARNMLYMSWDPKLAQIAKAWTKSCEFKHNPQLHSRIHPNFTALGENIWLGSLSIFSVSSAISAWYEEIKHYDFSTRKCRHVCGHYTQVVWADSYKLGCAVQLCPNGANFICDYGPAGNYPTWPYKQGATCSDCPKDDKCLNSLCINPRRDQVSRYYSVDYPDWPIYLRNRYT
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Protein Length
Partial
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Molecular Weight
27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GLIPR1 (GLI pathogenesis-related 1) is a gene that has garnered significant attention in recent years due to its potential implications in cancer biology and therapeutic interventions. Originally identified as a tumor suppressor, GLIPR1 plays a crucial role in regulating cell proliferation, differentiation, and apoptosis, making it an attractive target for cancer research. Its re-expression has been associated with the inhibition of tumor growth in various malignancies, suggesting that GLIPR1 acts as a negative regulator of tumor development. The study of GLIPR1 recombinant proteins allows researchers to elucidate the functional mechanisms underlying its antitumor activity, as well as to explore its potential as a biomarker for cancer diagnosis or prognosis. Moreover, understanding the structure-function relationship of GLIPR1 can facilitate the development of novel therapeutic strategies, including targeted therapies or gene editing approaches to restore its function in cancerous cells. Investigating GLIPR1 also opens avenues for exploring its interplay with other molecular pathways involved in cancer, thereby providing insights into the complex tumor microenvironment. Overall, the research on GLIPR1 recombinant proteins is pivotal for advancing our comprehension of cancer biology and for devising innovative treatments aimed at improving patient outcomes.
