Analytical Data
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Gene name
SCGB1A1
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简介
Uteroglobin/SCGB1A1 protein has multiple binding abilities and can interact with phosphatidylcholine, phosphatidylinositol, PCB, and binds weakly to progesterone.As a potent phospholipase A2 inhibitor, its antiparallel homodimer structure is maintained by disulfide bonds.SCGB1A1 Protein, Mouse (His) is the recombinant mouse-derived SCGB1A1 protein, expressed by E.coli , with N-6*His labeled tag.
- Application
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Biological Activity
Measured by the ability of the immobilized protein to affect the adhesion of the A549 human lung carcinoma cells in the presence of Fibronectin. The ED50 for this effect is 1.531 μg/mL, corresponding to a specific activity is 653.17 units/mg. Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells.The ED50 for this effect is 1.531 μg/mL, corresponding to a specific activity is 653.17 units/mg.
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Alternative Names
Scgb1a1; Cc10; Ugb; Utg; Uteroglobin; Clara cell 17 kDa protein; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; PCB-binding protein; Secretoglobin family 1A member 1
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Species
Mouse
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q06318
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Expression Region
D22-96F
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Protein Length
Full Length of Mature Protein
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Molecular Weight
9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the SCGB1A1 recombinant protein is rooted in its significant role in lung physiology and various pulmonary diseases. Secretoglobins, particularly SCGB1A1 (also known as Clara cell secretory protein, CCSP), are a family of secreted proteins predominantly expressed in the respiratory tract's Clara cells. SCGB1A1 serves several essential functions, including participating in lung development, modulating inflammation, and protecting lung tissues from oxidative stress and injury. Alterations in SCGB1A1 levels have been associated with several pathological conditions, such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer, making it a biomarker of interest in respiratory research. The recombinant production of SCGB1A1 allows for detailed structural and functional studies, offering insights into its molecular mechanisms and potential therapeutic applications. Furthermore, understanding SCGB1A1's role in lung diseases could lead to the development of novel diagnostic and therapeutic strategies, thereby improving patient management. Research on SCGB1A1 not only expands our knowledge of lung biology but also paves the way for innovative treatments that target specific pathways involved in respiratory disorders.
