Analytical Data
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基因名
CHRNa2
- Application
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别名
CHR-NA2; CHRN-A2; N-AChRA2; NAChRA2; N-AChR-A2; Neuronal Acetylcholine Receptor Alpha 2
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q91X60
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表达区间
Gln28~Leu241
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cholinergic receptors, particularly the nicotinic acetylcholine receptor (nAChR), play a crucial role in neurotransmission and are implicated in various physiological and pathological processes. Among the different subtypes, the alpha2 (CHRNa2) subunit is of particular interest due to its involvement in neurodevelopment and neurotransmitter release modulation. Research has shown that CHRNa2 can influence synaptic plasticity and cognitive function, making it a potential target for therapeutic interventions in neurological disorders such as Alzheimer's disease, schizophrenia, and addiction. Additionally, the production of recombinant CHRNa2 proteins allows for detailed structural and functional analyses, facilitating our understanding of receptor dynamics and pharmacological profiles. Studies focusing on the CHRNa2 subunit aim to elucidate its role in receptor oligomerization, ligand-binding affinity, and signal transduction mechanisms. As researchers explore the structural biology of CHRNa2 through techniques like X-ray crystallography and cryo-electron microscopy, the insights gained could lead to the development of more effective drugs that selectively target this receptor subtype, enhancing therapeutic strategies for various neuropsychiatric conditions.
