Analytical Data
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Gene name
GDI1
- Application
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Alternative Names
GDIL; MRX41; MRX48; OPHN2; RABGD1A; RABGDIA; XAP-4; Guanine Nucleotide Dissociation Inhibitor; Rab GDP Dissociation Inhibitor Alpha 1; Oligophrenin-2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31150
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Expression Region
Met1~Val274
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Molecular Weight
35kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDI1 (GDP dissociation inhibitor 1) is a crucial regulatory protein that plays a significant role in the control of the small GTPases, particularly the Ras and Rab families. These GTPases are vital for various cellular processes, including signal transduction, vesicle trafficking, and cell proliferation. Dysregulation of GDI1 and its associated pathways has been implicated in several diseases, including cancer and neurodegenerative disorders. Research on the recombinant GDI1 protein has gained momentum due to its potential therapeutic applications and the need to understand its functional mechanisms at a molecular level. Producing GDI1 as a recombinant protein allows for the detailed analysis of its structure, interactions with GTPases, and its effects in cellular contexts. Advances in recombinant protein technology have enabled the efficient expression and purification of GDI1, facilitating studies that explore its biochemical properties and regulatory functions. Investigating the role of GDI1 in cellular pathways not only enhances our understanding of GTPase-mediated signaling but also opens avenues for targeted therapeutic strategies that could address the consequences of GDI1 malfunction. As such, the study of recombinant GDI1 protein is a vital aspect of ongoing research efforts aiming to elucidate its role in cellular dynamics and its potential as a therapeutic target.
