Analytical Data
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基因名
CENPB
- Application
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别名
CENP-B; Major centromere autoantigen B
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07199
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表达区间
Gly2~Ser136
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分子量
19kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CENPB, or Centromere Protein B, plays a crucial role in the assembly and maintenance of the centromere, a specialized region of chromosomes essential for proper cell division. This protein is a vital component of the centromere complex, which ensures accurate segregation of chromosomes during mitosis and meiosis. Research into CENPB has gained significant attention due to its involvement in cell cycle regulation and its potential implications in cancer biology; aberrations in CENPB expression and function can lead to chromosomal instability, a hallmark of many tumors. Studies have shown that CENPB interacts with various other centromere-associated proteins and DNA, contributing to the structural integrity and functionality of the centromere. The recombinant expression of CENPB allows researchers to investigate its biochemical properties, interactions, and the mechanisms by which it influences chromosomal behavior. Furthermore, understanding CENPB at the molecular level offers insight into various diseases linked to centromere dysfunction, including cancer and genetic disorders. Therefore, the study of CENPB recombinant proteins is not only important for basic biological research but also holds therapeutic potential for developing strategies to target centromere-related pathologies. The growing body of knowledge surrounding CENPB could pave the way for innovative diagnostic and therapeutic approaches in oncology and other fields impacted by chromosomal abnormalities.
