Analytical Data
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Gene name
CD247
- Application
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Alternative Names
CD3-ZETA; CD3H; CD3Q; CD3Z; TCRZ; TCR-Z; T-Cell Receptor Zeta; CD3z Antigen; Zeta Polypeptide TiT3 Complex; T-cell receptor T3 zeta chain
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20963
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Expression Region
Arg52~Arg164
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Molecular Weight
17kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD247, also known as TCRζ (T-cell receptor zeta chain), is a crucial component of the T-cell receptor (TCR) complex, playing a vital role in T-cell activation, proliferation, and function. This protein is essential for both α/β and γ/δ T-cell signaling pathways, serving as a linker that transmits activation signals from the TCR to intracellular signaling cascades. Dysregulation of CD247 has been implicated in various immune disorders, including autoimmune diseases and certain cancers, making it a significant target for therapeutic interventions. Research into the recombinant expression of CD247 aims to provide insights into its structure-function relationship and facilitate the development of T-cell-based immunotherapies. By producing recombinant CD247, scientists can study its interaction with other TCR components and signaling molecules, paving the way for novel strategies to enhance T-cell responses against tumors or regulate aberrant immune reactions. Furthermore, understanding the regulatory mechanisms governing CD247 expression and function could lead to improved vaccine design and personalized medicine approaches in immunotherapy. As a result, the study of recombinant CD247 is a promising avenue for advancing our knowledge of T-cell biology and developing innovative therapeutic strategies to combat immune-related diseases.
