Analytical Data
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Gene name
ILKAP/PP2C delta
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简介
The ILKAP/PP2C delta protein is a key phosphatase that potentially regulates cell cycle progression by dephosphorylating substrates essential for proliferation. It selectively binds to ILK and regulates cell adhesion and growth factor signaling. ILKAP/PP2C delta Protein, Human (HEK293, His) is the recombinant human-derived ILKAP/PP2C delta protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Integrin-linked kinase-associated serine/threonine phosphatase 2C; ILKAP; PP2C delta
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9H0C8
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Expression Region
M1-H392
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AA Sequence
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
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Protein Length
Full Length
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Molecular Weight
46 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ILKAP (Integrin-Linked Kinase-Associated Protein) and PP2C (Protein Phosphatase 2C) delta are critical components in cellular signaling pathways that regulate various physiological processes, including cell adhesion, migration, and proliferation. Research on ILKAP/PP2C delta recombinant proteins has gained attention due to their potential implications in cancer biology and other diseases. ILKAP serves as a scaffolding protein that interacts with integrins and various signaling molecules, while PP2C delta functions as a phosphatase involved in dephosphorylating serine and threonine residues, thereby modulating kinase signaling pathways. The dysregulation of these proteins has been associated with enhanced tumor progression and metastasis, making their study vital for understanding tumor biology. Moreover, recombinant forms of these proteins enable researchers to investigate their functional roles, interaction networks, and regulatory mechanisms in a controlled environment. This can lead to the identification of novel therapeutic targets and biomarkers for cancer treatment. Thus, the study of ILKAP/PP2C delta recombinant proteins presents a promising avenue for advancing our understanding of cellular processes and developing innovative strategies for combating malignancies.
