Analytical Data
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Gene name
HIST1H1A
- Application
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Species
Human
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Source
HEK293
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q02539
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Expression Region
Ser2~Lys215
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Molecular Weight
35kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HIST1H1A, a gene encoding a histone protein, plays a critical role in the structural configuration of chromatin, influencing gene expression and DNA replication. As a member of the histone H1 family, HIST1H1A contributes to the stabilization of nucleosome formation and the overall compaction of chromatin, which is essential for maintaining genomic integrity. Recent studies have highlighted the significance of HIST1H1A in various biological processes, including cell cycle regulation, apoptosis, and differentiation. Abnormal expression of HIST1H1A has been linked to several diseases, particularly cancers, where it may contribute to the dysregulation of gene expression patterns. Given its pivotal role in chromatin dynamics, researchers have focused on recombinant HIST1H1A proteins to better understand its structure-function relationships and interactions with DNA and other nuclear proteins. These recombinant proteins provide valuable tools for investigating the mechanisms by which histones modulate chromatin architecture and gene regulation. Moreover, studying HIST1H1A may yield insights into epigenetic modifications and their implications in health and disease, paving the way for potential therapeutic applications targeting histone-based pathways. Understanding the functionality of HIST1H1A through recombinant protein studies thus remains a vital area of research in molecular biology and epigenetics.
