Analytical Data
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Gene name
Carboxylesterase 1
- Application
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Alternative Names
ACAT; CEH; CES2; HMSE1; PCE1; SES1; TGH; Retinyl ester hydrolase; Serine esterase 1; Triacylglycerol hydrolase; Egasyn; Cocaine carboxylesterase; Liver Carboxylesterase 1
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q63108
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Expression Region
His19~Leu300
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Molecular Weight
35kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Carboxylesterase 1 (CES1) is an important enzyme belonging to the carboxylesterase family, which plays a crucial role in the metabolism of a variety of endogenous and exogenous compounds, including drugs and toxic substances. Research on CES1 is of significant interest due to its involvement in drug metabolism, as it can hydrolyze ester and amide bonds in numerous pharmacological agents, thus influencing drug efficacy and toxicity. The understanding of CES1 is particularly relevant in the context of personalized medicine, where individual variations in CES1 activity can lead to differences in drug response among patients. Recombinant CES1 protein studies facilitate the exploration of its biochemical properties, substrate specificities, and interactions with various inhibitors. These studies are vital for elucidating the enzyme's role in pharmacokinetics and its potential implications in drug development and safety assessment. Additionally, recombinant CES1 can serve as a valuable tool for screening novel drug candidates and assessing their metabolic stability. Overall, the research on recombinant Carboxylesterase 1 not only enhances our understanding of metabolic processes but also supports the advancement of therapeutic strategies designed to improve patient outcomes through tailored drug therapies.
