Analytical Data
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基因名
PDZD11
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简介
PDZD11 protein is a key mediator that promotes the docking of ADAM10 to adhesion zonules by interacting with PLEKHA7. PDZD11 is critical for subsequent binding to TSPAN33, which orchestrates complex protein-protein interactions at cellular junctions. PDZD11 Protein, Human (His) is the recombinant human-derived PDZD11 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
PDZ domain-containing protein 11; PMCA-interacting single-PDZ protein; AIPP1; PDZK11; PISP
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q5EBL8-1
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表达区间
D2-H140
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蛋白长度
Partial
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDZD11, or PDZ domain-containing protein 11, is a member of the PDZ protein family, which plays crucial roles in cellular signaling, synaptic transmission, and the organization of protein complexes. Research into PDZD11 has gained momentum due to its potential involvement in various biological processes and human diseases. Notably, this protein is linked to the regulation of ion channels and receptors, thereby influencing neuronal function and plasticity. Studies suggest that PDZD11 may interact with other critical proteins, potentially impacting pathways associated with neurodegenerative diseases and cancer. The recombinant expression of PDZD11 provides a valuable tool for investigating its structural and functional properties, which may aid in the elucidation of its role in health and disease. Characterizing its interactions at the molecular level can lead to a better understanding of disease mechanisms, ultimately paving the way for novel therapeutic approaches. Furthermore, the study of PDZD11 can contribute to the broader understanding of PDZ domain-containing proteins, which are critical in maintaining cellular architecture and signaling pathways. Overall, the exploration of PDZD11 and its recombinant protein is essential for advancing knowledge in cellular biology and developing strategies for managing related disorders.
