Analytical Data
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Gene name
PDZD11
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简介
PDZD11 protein is a key mediator that promotes the docking of ADAM10 to adhesion zonules by interacting with PLEKHA7. PDZD11 is critical for subsequent binding to TSPAN33, which orchestrates complex protein-protein interactions at cellular junctions. PDZD11 Protein, Human (His) is the recombinant human-derived PDZD11 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
PDZ domain-containing protein 11; PMCA-interacting single-PDZ protein; AIPP1; PDZK11; PISP
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q5EBL8-1
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Expression Region
D2-H140
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Protein Length
Partial
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Molecular Weight
18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDZD11, or PDZ domain-containing protein 11, is a member of the PDZ protein family, which plays crucial roles in cellular signaling, synaptic transmission, and the organization of protein complexes. Research into PDZD11 has gained momentum due to its potential involvement in various biological processes and human diseases. Notably, this protein is linked to the regulation of ion channels and receptors, thereby influencing neuronal function and plasticity. Studies suggest that PDZD11 may interact with other critical proteins, potentially impacting pathways associated with neurodegenerative diseases and cancer. The recombinant expression of PDZD11 provides a valuable tool for investigating its structural and functional properties, which may aid in the elucidation of its role in health and disease. Characterizing its interactions at the molecular level can lead to a better understanding of disease mechanisms, ultimately paving the way for novel therapeutic approaches. Furthermore, the study of PDZD11 can contribute to the broader understanding of PDZ domain-containing proteins, which are critical in maintaining cellular architecture and signaling pathways. Overall, the exploration of PDZD11 and its recombinant protein is essential for advancing knowledge in cellular biology and developing strategies for managing related disorders.
