Analytical Data
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Gene name
LAMTOR2
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简介
LAMTOR2 is a key component of the Ragulator complex, which centralizes amino acid sensing and mTORC1 activation in response to stimuli such as growth factors, energy levels, and amino acids. As an amino acid-activated guanine nucleotide exchange factor (GEF), the Ragulator complex recruits Rag GTPases (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC, and/or RagD/RRAGD) to the lysosomal membrane. LAMTOR2 Protein, Human (His) is the recombinant human-derived LAMTOR2 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Ragulator complex protein LAMTOR2; MAPBP-interacting protein; MAPBPIP; ROBLD3; HSPC003
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9Y2Q5-1
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Expression Region
M1-S125
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Protein Length
Full Length of Isoform-1
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Molecular Weight
13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LAMTOR2, a key component of the late endosomal/lysosomal complex, plays a crucial role in intracellular signaling pathways, particularly in the context of mTORC1 (mechanistic Target of Rapamycin Complex 1) activation. Research suggests that LAMTOR2 facilitates nutrient sensing and regulates cellular responses to growth factors, thereby influencing cell proliferation and metabolism. Its involvement in lysosomal dynamics is essential for proper autophagy and degradation of cellular components. Dysregulation of the LAMTOR2 protein has been associated with various diseases, including cancers and metabolic disorders, making it a significant target for therapeutic intervention. Understanding its structural and functional properties through recombinant protein studies is vital for elucidating the molecular mechanisms underlying these pathways. Advances in techniques for producing and purifying LAMTOR2 may also enable the development of specific inhibitors or modulators, offering potential strategies for clinical applications in the treatment of related diseases. Therefore, ongoing research into LAMTOR2 serves as an important avenue for enhancing our knowledge of cell biology and developing novel therapeutic approaches.
