Analytical Data
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基因名
CEP57
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简介
CEP57 is a centrosomal protein that is a potential player in promoting microtubule attachment to centrosomes, possibly by forming a ring-like structure around microtubules. The protein exhibits homodimer and homooligomer formation and interacts with microtubules. CEP57 Protein, Human (GST) is the recombinant human-derived CEP57 protein, expressed by E. coli , with N-GST labeled tag.
- Application
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别名
Centrosomal protein of 57 kDa; Cep57; Translokin; KIAA0092; TSP57
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q86XR8
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表达区间
S118-R226
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蛋白长度
Partial
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分子量
14 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CEP57, or centrosomal protein 57, is a pivotal member of the CEP family, which plays a critical role in centrosome function and stability. Research into CEP57 has gained attention due to its involvement in various cellular processes, including mitosis, cell cycle regulation, and ciliary function. It is located at the centrosome, a cellular structure essential for proper spindle formation and chromosome segregation during cell division. Abnormalities in CEP57 have been associated with several diseases, notably cancer and ciliopathies, where dysregulation can lead to genomic instability and defective cellular signaling pathways. Given its significance in maintaining cellular integrity, many studies are focused on understanding the molecular mechanisms by which CEP57 interacts with other centrosomal proteins and how its dysfunction contributes to disease pathogenesis. Investigating the recombinant expression of CEP57 offers opportunities to elucidate its structure-function relationships, paving the way for potential therapeutic strategies aimed at correcting its dysregulation. Overall, the exploration of CEP57 not only enhances our understanding of centrosome biology but also highlights its potential as a biomarker or target for therapeutic intervention in related diseases.
