Analytical Data
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Gene name
CABP5
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简介
The CABP5 protein acts as an inhibitor to regulate calcium-dependent inactivation of L-type calcium channels, converting the voltage dependence of activation to a more depolarizing membrane potential. It is involved in the transmission of light signals and may positively regulate endocytosis and exocytosis of neurotransmitter vesicles in a salt-dependent manner. CABP5 Protein, Human (His) is the recombinant human-derived CABP5 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Calcium-binding protein 5; CABP5; CABP3
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NP86
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Expression Region
M1-R173
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CABP5, or Calcium-Binding Protein 5, is a member of the calmodulin superfamily and is primarily expressed in the retina and the central nervous system. It plays a crucial role in calcium signaling pathways, influencing various cellular processes such as neurotransmitter release, synaptic plasticity, and phototransduction. Research into CABP5 has gained prominence due to its potential implications in retinal diseases and neurodegenerative disorders. Mutations or dysregulation of CABP5 have been linked to conditions like retinitis pigmentosa, highlighting its importance in photoreceptor function. Furthermore, the understanding of its interaction with other proteins, especially those involved in calcium-dependent signaling, can provide insights into the molecular mechanisms underpinning synaptic relationships and neuronal communication. The study of CABP5 as a recombinant protein aims to elucidate its structure-function relationship and biophysical properties, facilitating drug design and therapeutic interventions targeting calcium dysregulation in both retinal and neurological contexts. This research is essential for developing innovative strategies to treat or mitigate the effects of diseases associated with CABP5 dysfunction, ultimately contributing to advances in targeted gene therapies and personalized medicine for affected individuals.
