Analytical Data
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Gene name
VTI1A
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简介
VTI1A protein is a V-SNARE that mediates vesicle trafficking and promotes lipid bilayer fusion by interacting with t-SNARE on target membranes. It plays a role in vesicle trafficking from late endosomes to the trans-Golgi network. VTI1A Protein, Human (HEK293, His) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-His labeled tag.
- Application
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Alternative Names
Vesicle transport through interaction with t-SNAREs homolog 1A; Vti1-rp2
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Species
Human
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Source
HEK293
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96AJ9-2
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Expression Region
M1-R187
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AA Sequence
MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRILTGMLRR
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Protein Length
Partial
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Molecular Weight
29&25&20 kDa kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The VTI1A protein, a member of the vesicle transport and docking factor family, plays a crucial role in intracellular membrane trafficking and the regulation of exocytosis. Its involvement in the transport of vesicles to their target membranes is essential for maintaining cellular homeostasis and facilitating various physiological processes. Recent studies have highlighted VTI1A’s potential implications in neurodegenerative diseases and cancer, making it a subject of increasing interest in biomedical research. The ability of VTI1A to influence synaptic function and neurotransmitter release underlines its importance in neuronal communication, while aberrations in its function are linked to impaired vesicle transport and cognitive decline. Additionally, VTI1A is implicated in tumor progression, where its expression levels correlate with malignancy and metastatic potential. Given these associations, developing VTI1A recombinant proteins is critical for advancing our understanding of its biological functions and mechanisms. Such proteins can be utilized in various applications, ranging from investigating protein-protein interactions to exploring targeted therapeutic strategies aimed at modulating VTI1A activity in disease contexts. Overall, the study of VTI1A and its recombinant forms stands at the intersection of fundamental cellular biology and innovative therapeutic development, paving the way for new insights into the molecular underpinnings of health and disease.
