Analytical Data
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基因名
VTI1A
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简介
VTI1A protein is a V-SNARE that mediates vesicle trafficking and promotes lipid bilayer fusion by interacting with t-SNARE on target membranes. It plays a role in vesicle trafficking from late endosomes to the trans-Golgi network. VTI1A Protein, Human (HEK293, His) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-His labeled tag.
- Application
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别名
Vesicle transport through interaction with t-SNAREs homolog 1A; Vti1-rp2
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种属
Human
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表达系统
HEK293
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96AJ9-2
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表达区间
M1-R187
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氨基酸序列
MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARERLRETDANLGKSSRILTGMLRR
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蛋白长度
Partial
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分子量
29&25&20 kDa kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The VTI1A protein, a member of the vesicle transport and docking factor family, plays a crucial role in intracellular membrane trafficking and the regulation of exocytosis. Its involvement in the transport of vesicles to their target membranes is essential for maintaining cellular homeostasis and facilitating various physiological processes. Recent studies have highlighted VTI1A’s potential implications in neurodegenerative diseases and cancer, making it a subject of increasing interest in biomedical research. The ability of VTI1A to influence synaptic function and neurotransmitter release underlines its importance in neuronal communication, while aberrations in its function are linked to impaired vesicle transport and cognitive decline. Additionally, VTI1A is implicated in tumor progression, where its expression levels correlate with malignancy and metastatic potential. Given these associations, developing VTI1A recombinant proteins is critical for advancing our understanding of its biological functions and mechanisms. Such proteins can be utilized in various applications, ranging from investigating protein-protein interactions to exploring targeted therapeutic strategies aimed at modulating VTI1A activity in disease contexts. Overall, the study of VTI1A and its recombinant forms stands at the intersection of fundamental cellular biology and innovative therapeutic development, paving the way for new insights into the molecular underpinnings of health and disease.
