Analytical Data
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基因名
TSC22/TSC22D1
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简介
TSC22D1 Protein, a positive modulator of cell death during mammary gland involution in response to TGFB3, forms a heterodimer with TSC22D4/THG1. Its interactions with histone H1-2 and GNL3 underscore TSC22D1's versatile role in molecular processes, emphasizing its potential significance in various cellular contexts. TSC22/TSC22D1 Protein, Human (His) is the recombinant human-derived TSC22/TSC22D1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
TSC22 domain family protein 1; Cerebral protein 2; KIAA1994; TGFB1I4
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15714-2
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表达区间
M1-A144
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蛋白长度
Full Length of Isoform-2
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分子量
19-20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TSC22/TSC22D1 is a member of the TSC22 family of proteins, which play significant roles in various cellular processes, including immune responses, cell differentiation, and stress responses. Originally identified as a gene induced during T cell activation, TSC22D1 has garnered attention for its regulatory functions in inflammatory diseases, autoimmune conditions, and cancer. Research has shown that TSC22D1 acts as a transcriptional repressor, modulating the expression of genes associated with inflammatory pathways, thereby influencing the balance between pro-inflammatory and anti-inflammatory signals. Furthermore, its expression levels are closely tied to various cellular contexts, highlighting its potential as a therapeutic target. Understanding the precise mechanisms of TSC22D1 function can provide insights into its role in cellular homeostasis and disease pathology, making it a crucial subject of study in molecular biology and therapeutic development. Moreover, recombinant TSC22D1 protein can be utilized in various assays and experimental setups to elucidate its functional properties and interactions with other biomolecules, underscoring the importance of this protein in both basic and applied research.
