Analytical Data
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Gene name
TMED9
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简介
TMED9 is a key player in vesicle protein trafficking and plays an important role in the early secretory pathway, particularly in COPI vesicle-mediated retrograde transport. It promotes the recruitment of coat isoforms to the membrane, enhances ARFGAP2 activity, and ensures the specific retention of p24 complexes in cis-Golgi membranes, specifically affecting TMED2 and TMED10 localization. TMED9 Protein, Human (HEK293, His) is the recombinant human-derived TMED9 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVK6
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Expression Region
L38-R202
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Protein Length
Lumenal Domain
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Molecular Weight
20.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED9, a member of the translocation associated membrane proteins (TMED) family, has garnered attention due to its crucial role in the intracellular transport and regulation of various proteins, particularly in the endoplasmic reticulum-Golgi network. Research indicates that TMED9 is involved in the maturation and secretion of glycoproteins, and its dysfunction is linked to several diseases, including cancer and neurodegenerative disorders. The study of TMED9 recombinant proteins aims to elucidate its structure-function relationships and to explore its potential as a therapeutic target. By producing TMED9 in a recombinant form, researchers can investigate its biochemical properties, interaction with other cellular components, and its role in disease mechanisms. Furthermore, understanding TMED9's functional dynamics could pave the way for the development of novel strategies to modulate its activity, potentially leading to medical advancements in targeting the pathways associated with its dysfunction. Overall, the exploration of TMED9 recombinant proteins is a compelling area of study that intersects cellular biology, biochemistry, and therapeutic innovation.
