Analytical Data
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基因名
SCN3B
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简介
The SCN3B protein critically affects sodium channel dynamics, inducing unique sustained currents and slower inactivation rates compared to beta-1. Its interaction with NFASC is shown to guide sodium channels to the nodes of Ranvier during axonal development and retain them in mature myelinated axons. SCN3B Protein, Human (HEK293, His) is the recombinant human-derived SCN3B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Sodium channel subunit beta-3; SCN3B; KIAA1158
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9NY72
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表达区间
F23-E159
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蛋白长度
Partial
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分子量
23-34 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMOC1, or SMAD specific E3 ubiquitin protein ligase 1, is an important component in the regulatory framework of cellular signaling pathways, particularly those involving TGF-β (Transforming Growth Factor-beta) and BMP (Bone Morphogenetic Protein) signaling. Research has indicated that SMOC1 plays a critical role in the modulation of cellular processes such as proliferation, differentiation, and apoptosis. Its dysregulation has been linked to various pathologies, including fibrosis, cancer progression, and developmental disorders. The ability of SMOC1 to interact with other proteins and influence their stability through ubiquitination makes it a key player in maintaining cellular homeostasis. Consequently, understanding the structure and function of recombinant SMOC1 protein has garnered significant interest in the scientific community. Researchers are particularly focused on elucidating its molecular mechanisms, which could reveal novel therapeutic targets for diseases associated with TGF-β and BMP signaling pathways. By producing and characterizing recombinant SMOC1, scientists aim to explore its functional roles in cellular signaling and potential implications in disease, enhancing our overall understanding of this multifaceted protein.
