Analytical Data
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Gene name
SCN3B
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简介
The SCN3B protein critically affects sodium channel dynamics, inducing unique sustained currents and slower inactivation rates compared to beta-1. Its interaction with NFASC is shown to guide sodium channels to the nodes of Ranvier during axonal development and retain them in mature myelinated axons. SCN3B Protein, Human (HEK293, His) is the recombinant human-derived SCN3B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Sodium channel subunit beta-3; SCN3B; KIAA1158
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9NY72
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Expression Region
F23-E159
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Protein Length
Partial
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Molecular Weight
23-34 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMOC1, or SMAD specific E3 ubiquitin protein ligase 1, is an important component in the regulatory framework of cellular signaling pathways, particularly those involving TGF-β (Transforming Growth Factor-beta) and BMP (Bone Morphogenetic Protein) signaling. Research has indicated that SMOC1 plays a critical role in the modulation of cellular processes such as proliferation, differentiation, and apoptosis. Its dysregulation has been linked to various pathologies, including fibrosis, cancer progression, and developmental disorders. The ability of SMOC1 to interact with other proteins and influence their stability through ubiquitination makes it a key player in maintaining cellular homeostasis. Consequently, understanding the structure and function of recombinant SMOC1 protein has garnered significant interest in the scientific community. Researchers are particularly focused on elucidating its molecular mechanisms, which could reveal novel therapeutic targets for diseases associated with TGF-β and BMP signaling pathways. By producing and characterizing recombinant SMOC1, scientists aim to explore its functional roles in cellular signaling and potential implications in disease, enhancing our overall understanding of this multifaceted protein.
