Analytical Data
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Gene name
PDRG1
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简介
As a component of the PAQosome complex, the PDRG1 protein may play a role in chaperone-mediated protein folding. PAQosome is composed of multiple protein complexes, including PDRG1, and coordinates the biogenesis of multiple protein complexes. PDRG1 Protein, Human (His) is the recombinant human-derived PDRG1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
p53 and DNA damage-regulated protein 1; PDRG1; C20orf126; PDRG
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NUG6
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Expression Region
M1-G133
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Protein Length
Full Length
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDRG1, or P53-Dependent Repressor Gene 1, is a protein that has garnered significant interest in cancer research due to its role in cellular processes such as apoptosis, cell cycle regulation, and response to stress. Initially identified as a gene upregulated by the tumor suppressor protein p53, PDRG1 has been implicated in various malignancies, including lung, breast, and gastrointestinal cancers. Its overexpression is often associated with poor prognosis, suggesting that PDRG1 may play a crucial role in tumorigenesis and cancer progression. Research has shown that PDRG1 may act as a regulator of key signaling pathways, influencing cellular growth and survival mechanisms. Furthermore, the protein has been linked to drug resistance in cancer treatment, underscoring its potential as a therapeutic target. As such, recombinant PDRG1 protein studies are crucial, enabling the exploration of its functional properties, interaction with other cellular components, and its role in modulating the cellular response to anti-cancer therapies. Understanding the detailed mechanisms by which PDRG1 operates may open new avenues for targeted therapies and improve treatment outcomes for patients with PDRG1-associated tumors.
